excitotoxicity

excitotoxicity
The continuous stimulation of a nerve cell by a neurotransmitter, especially by glutamates

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  • Excitotoxicity — is the pathological process by which nerve cells are damaged and killed by glutamate and similar substances. This occurs when receptors for the excitatory neurotransmitter glutamate such as the NMDA receptor and AMPA receptor are overactivated.… …   Wikipedia

  • excitotoxicIty — ex·ci·to·tox·ic·I·ty (ek si″to tok sisґĭ te) 1. the quality of being excitotoxic. 2. the degree to which a given substance has an excitotoxic effect on the nervous system …   Medical dictionary

  • excitotoxicity — ex·ci·to·tox·ic·i·ty …   English syllables

  • excitotoxicity — noun see excitotoxic …   Useful english dictionary

  • NMDA receptor antagonist — Ketamine, one of the most common NMDA receptor antagonists. NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N methyl d aspartate receptor (NMDAR). They are used as anesthesia for animals …   Wikipedia

  • Metabotropic glutamate receptor — fluorescent micrographs of cells expressing mGluR1 labeled with green fluorescent protein[1] The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are… …   Wikipedia

  • Chloride potassium symporter 5 — Solute carrier family 12 (potassium/chloride transporter), member 5 Identifiers Symbols SLC12A5; KCC2; KIAA1176 External IDs …   Wikipedia

  • Glutamic acid — Glutamic acid …   Wikipedia

  • Rimonabant — drugbox IUPAC name = 5 (4 Chlorophenyl) 1 (2,4 dichloro phenyl) 4 methyl N (piperidin 1 yl) 1 H pyrazole 3 carboxamide width = 220 CAS number = 158681 13 1 ATC prefix = A08 ATC suffix = AX01 PubChem = 104850 DrugBank = C=22|H=21|Cl=3|N=4|O=1… …   Wikipedia

  • Memantine — Systematic (IUPAC) name 3,5 dimethyltricyclo[3.3.1.13,7] …   Wikipedia

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